Table:

Characteristic features of precursor states and proposed monitoring guideline

	Myelodysplastic syndrome	Idiopathic cytopenia of unknown significance	Clonal haematopoiesis of indeterminate potential	Clonal cytopenia of unknown significance
Cytopenias	+	+	−	+
Dysplasia	+	−	−	−
Clonality	+	−	+	+
Risk of transformation to AML	++	↓↓↓	↓(↓)	↓↑
Monitoring	Per consensus guidelines by disease stage	No need to reassess next-generation sequencing; monitoring 2–4 times per year CBC	Observation; routine CBC for health maintenance	Observation; monitoring 2–4 times per year; supportive care

The proposed guidelines are based on currently available data for surveillance of these conditions; certainly all monitoring plans should be guided by a patient’s clinical scenario including age, expectation, specific mutations, and comorbid conditions. CBC=cell blood count. + sign=present. − sign= absent. Arrows indicate increase or decrease.