Table 2.

Flow of records by search strategy

Species	No of papers
	Title screening step	Title/abstract screening step	Article evaluation step (screening for potential relevance)a	Article evaluation step (identification of potential safety concerns)
Bacteria	2,244	258	224	11
Bacillus spp.	804	199	199b	2
Geobacillus stearothermophilus			0	0
Bifidobacterium spp.	206	21	3	1
Carnobacterium divergens			0	0
Corynebacterium glutamicum	45	0	0	0
Gluconobacter oxydans	115	1	0	0
Xanthomonas campestris			0	0
Lactobacillus spp.	555	22	12	3
Lactococcus lactis	173	6	4	3
Leuconostoc spp.	68	5	4	1
Microbacterium imperiale			0	0
Oenococcus oeni	24	1	0	0
Pasteuria nishizawae			0	0
Pediococcus spp.	146	2	2	1
Propionibacterium spp.	27	0	0	0
Streptococcus thermophilus	81	1	0	0
Viruses	108	0	0	0
Alphaflexiviridae	39	0	0	0
Potyviridae				0
Baculoviridae	69	0	0	0
Yeasts	1,358	273	268 b	30 c
Candida famata (teleomorph = Debaryomyces hansenii)	1,358	273	268	10
Candida kefyr (teleomorph = Kluyveromyces marxianus)				16
Candida pelliculosa (synonymus = Pichia anomala) (teleomorph = Wickerhamomyces anomalus)				6
Candida utilis (teleomorph = Lindnera jadinii)				1
Hanseniaspora uvarum				1
Saccharomyces cerevisiae including Saccharomyces boulardii				8
Kluyveromyces lactis				1
Schizosaccharomyces pombe				1
Total	3,710	531	492	85
Excluded	3,179	39	407

^aRelevant references in Appendix D.

^bThe relatively high number of hits is linked to the procedure followed for the screening of references using machine learning techniques (MLT) in parallel with experts’ selection.

^c30 articles describing 45 studies related to different yeast species. In one case, there was no reference to any particular species.