Table 2.
Risk Factors for Thrombosis: Demographic, Clinical Data, and Treatment Modalities of Adult Patients With Cushing Syndrome Subdivided by Patients With TEs and Without TEs
| Characteristic | Patients With TE (n = 39) | Patients Without TE (n = 167) | P | OR | 95%CI |
|---|---|---|---|---|---|
| Age at time of event, y ± SD | 49 ± 13.5 | 43 ± 13.5 | |||
| Female, n, % | 30, 81 | 133, 78.7 | .69 | 0.83 | 0.34-2.05 |
| Male, n, % | 7, 19 | 36, 21 | .69 | 0.83 | 0.34-2.05 |
| Body mass index ± SD | 33.3 ± 7.5 | 34 ± 8.6 | .69 | 0.99 | 0.95-1.03 |
| Smoker, n, % | 14, 37.8 | 55, 32.5 | .57 | 1.35 | 0.65-2.79 |
| Hypertension, n, % | 28, 75.6 | 117, 69.2 | .38 | 1.43 | 0.63-3.24 |
| Diabetes mellitus, n, % | 15, 40.5 | 71, 42 | .77 | 0.90 | 0.44-1.85 |
| Estrogena, n, % | 3, 7.14 | 39, 92.86 | .62 | b | b |
| Testosteronea, n, % | 3, 13.1 | 17, 73.9 | .59 | b | b |
| Cushing disease, n, % | 35, 18.8 | 151, 81.2 | .005 | 1.04 | 0.33-3.27 |
| Adrenal Cushing syndrome, n, % | 2, 14.3 | 12, 85.7 | .19 | b | b |
| Ectopic Cushing, n, % | 2, 25 | 6, 75 | .21 | b | b |
| TSS, n, % | 36, 19.15 | 152, 80.85 | .35 | 2.01 | 0.44-9.10 |
| BLA, n, % | 14, 38.88 | 22, 61.11 | .001 | 3.74 | 1.69-8.27 |
| Pituitary radiation, n, % | 5, 21.74 | 18, 78.26 | .65 | 1.27 | 0.44-3.67 |
Abbreviations: BLA, bilateral adrenalectomy; OR, odds ratio; TE, thrombotic event; TSS, transsphenoidal surgery.
aAnalysis comparing individuals who were taking estrogen and testosterone supplementation at the time of TE compared to patients without TE who were ever treated with estrogen or testosterone.
bSample size was too small to calculate statistical significance.