Table D.2.

Genotoxicity data (in vivo)

Chemical name [FL‐no]	Test system	Test object	Route	Dose	Reported result	Reference	Commentsa
Methyl α‐ionone [07.009]	Micronucleus formation	NMRI mice, male and female, bone marrow	I.P.	825–2063 mg/kg bw	Negative	Wild et al. (1983)	Limited validity (only analysis at one time point; no PCE/NCE ratio reported)
	Sex‐linked recessive lethals	Drosophila melanogaster	Feed	20 mM	Negative		Limited validity (limited reporting, test system considered of limited relevance)

^a

Validity of genotoxicity studies:

• Valid.
• Limited validity (e.g. if certain aspects are not in accordance with OECD Guidelines or current standards and/or limited documentation).
• Insufficient validity (e.g. if main aspects are not in accordance with any recognised guidelines (e.g. OECD) or current standards and/or inappropriate test system).
• Validity cannot be evaluated (e.g. insufficient documentation, short abstract only, too little experimental details provided).