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. 2019 May 22;17(5):e05676. doi: 10.2903/j.efsa.2019.5676

Table E.2.

In vivo genotoxicity data evaluated in FGE.210Rev1

Chemical name [FL‐no] Test system Test object Route Dose Reported result Reference Comments
α‐Ionone [07.009] Micronucleus formation Male and female mice Gavage 300, 600 and 1,200 mg/kg bw per day Negative Krsmanovic and Huston (2006) Complies with draft OECD Guideline 474. Evidence of bone marrow toxicity as evidenced by reductions in polychromatic erythrocytes observed at 24 h after dosing and in a satellite group at the top dose 48 h after dosing