Table E.2.

In vivo genotoxicity data evaluated in FGE.210Rev1

Chemical name [FL‐no]	Test system	Test object	Route	Dose	Reported result	Reference	Comments
α‐Ionone [07.009]	Micronucleus formation	Male and female mice	Gavage	300, 600 and 1,200 mg/kg bw per day	Negative	Krsmanovic and Huston (2006)	Complies with draft OECD Guideline 474. Evidence of bone marrow toxicity as evidenced by reductions in polychromatic erythrocytes observed at 24 h after dosing and in a satellite group at the top dose 48 h after dosing