Table A.1.
Estimation of user exposure to endotoxins from the additive l‐histidine produced by Escherichia coli K‐12 NITE BP‐02526 including consideration of using filter half mask (FF P2 or FF P3)36 as a preventative measure
| Calculation | Identifier | Description | Amount | Source |
|---|---|---|---|---|
| a | Endotoxin content IU/g product | 34,900 | Technical dossier | |
| b | Dusting potential (g/m3) | 0.93 | Technical dossier | |
| a × b | c | Endotoxin content in the air (IU/m3) | 32,457 | |
| d | No of premixture batches made/working day | 40 | EFSA FEEDAP Panel (2012) | |
| e | Time of exposure (s)/production of one batch | 20 | EFSA FEEDAP Panel (2012) | |
| d × e | f | Total duration of daily exposure/worker (s) | 800 | |
| g | Uncertainty factor | 2 | EFSA FEEDAP Panel (2012) | |
| f × g | h | Refined total duration of daily exposure (s) | 1,600 | |
| h/3 600 | i | Refined total duration of daily exposure (h) | 0.44 | |
| j | Inhaled air (m3)/eight‐hour working day | 10 | EFSA FEEDAP Panel (2012) | |
| j/8 × i | k | Inhaled air during exposure (m3) | 0.56 | |
| c × k | l | Endotoxin inhaled (IU) during exposure/eight‐hour working day | 18,031 | |
| m | Health‐based recommended exposure limit of endotoxin (IU/m3)/eight‐hour working day | 90 | Health Council of the Netherlands (2010) | |
| m × j | n | Health‐based recommended exposure limit of total endotoxin exposure (IU)/eight‐hour working day | 900 | |
| l/10 | Endotoxins inhaled (IU)/eight‐hour working day reduced by filter half mask FF P2 (reduction factor 10) | 1,803 | ||
| l/20 | Endotoxins inhaled (IU)/eight‐hour working day reduced by filter half mask FF P3 (reduction factor 20) | 902 |