Table B.2.
Evaluation status of hydrolysis products of candidate esters in FGE.05Rev3
| FL‐no | EU Union List chemical name JECFA no | Structural formula | SCF statusa JECFA status CoE statusb EFSA status | Structural class Procedure path (JECFA)c | Comments |
|---|---|---|---|---|---|
| 4‐Hepten‐2‐ol |
|
Not evaluated as flavouring substance | Not in Union List | ||
| Hexadecanoic acid |
|
Not evaluated as flavouring substance | Not in Union List | ||
| Allyl alcohol | Not evaluated as flavouring substance | Not in Union List; JECFA ADI available (JECFA, 1996) | |||
| 02.001 |
2‐Methylpropan‐1‐ol 251 |
|
Category 1 (SCF, 1995) No safety concern (JECFA, 1999 Category A (CoE, 1992) |
Class I A3: Intake below threshold |
|
| 02.002 |
Propan‐1‐ol 82 |
|
Category 1 (SCF, 1995) No safety concern (JECFA, 1999) Category A (CoE, 1992) |
Class I A3: Intake above threshold, A4: Endogenous |
|
| 02.003 |
Isopentanol 52 |
|
Category 1 (SCF, 1995) No safety concern (JECFA, 1997) Category A (CoE, 1992) |
Class I A3: Intake below threshold |
|
| 02.004 |
Butan‐1‐ol 85 |
|
Category 1 (SCF, 1995) No safety concern (JECFA, 1999) Category A (CoE, 1992) |
Class I A3: Intake above threshold, A4: Endogenous |
|
| 02.005 |
Hexan‐1‐ol 91 |
|
Category 1 (SCF, 1995) No safety concern (JECFA, 1999) Category A (CoE, 1992) |
Class I A3: Intake above threshold, A4: Endogenous |
|
| 02.040 |
Pentan‐1‐ol 88 |
|
Category 1 (SCF, 1995) No safety concern (JECFA, 1999) Category A (CoE, 1992) |
Class I A3: Intake below threshold |
|
| 02.076 |
2‐Methylbutan‐1‐ol 1199 |
|
Category 1 (SCF, 1995) No safety concern (JECFA, 2004b) Category B (CoE, 1992) FGE.76 |
Class I A3: Intake below threshold |
|
| 02.078 |
Ethanol 41 |
|
Category 1 (SCF, 1995) No safety concern (JECFA, 1997) |
No evaluation | At the 46th meeting (1996), the Committee concluded that ethanol posed no safety concern at its current level of intake when ethyl esters are used as flavouring agents |
| 02.079 |
Isopropanol 277 |
|
Category 1 (SCF, 1995) No safety concern (JECFA, 2000a) |
Class I A3: Intake above threshold, A4: Endogenous |
|
| 02.112 | Non‐2(cis)‐en‐1‐ol |
|
No safety concern (JECFA, 2004b) FGE.200Rev1 |
Class I A3: Intake below threshold |
Evaluated in FGE.200Rev1 as of no genotoxicity concern. Pending the finalisation of safety evaluation in FGE.71Rev1 |
| 02.090 |
Non‐(2E)‐en‐1‐ol 1365 |
|
No safety concern (JECFA, 2005) FGE.200Rev1 |
Class I A3: Intake below threshold |
Evaluated in FGE.200Rev1 as of no genotoxicity concern. Pending the finalisation of safety evaluation in FGE.71Rev1 |
| 02.156 | Hex‐2(cis)‐en‐1‐ol |
|
No safety concern (JECFA, 2004b) FGE.200Rev1 |
Class I A3: Intake below threshold |
Evaluated in FGE.200Rev1 as of no genotoxicity concern. Pending the finalisation of safety evaluation in FGE.71Rev1 |
| 02.157 | Hex‐(2E)‐en‐1‐ol |
|
Evaluation request withdrawn from FGE.200 | Not in the UL (as no longer supported by Industry) | |
| 08.002 | Acetic acid |
|
Category 1 (SCF, 1995) No safety concern (JECFA, 1999) Category A (CoE, 1992) |
Class I A3: Intake above threshold, A4: Endogenous |
|
| 08.007 | Valeric acid |
|
Category 1 (SCF, 1995) No safety concern (JECFA, 2000) Category A (CoE, 1992) |
Class I A3: Intake below threshold |
|
| 08.038 | Phenylacetic acid |
|
No safety concern (JECFA, 2000) Category B (CoE, 1992) FGE.53 |
Class I A3: Intake below threshold |
|
| 08.013 |
Oleic acid 333 |
|
Category 1 (SCF, 1995) No safety concern (JECFA, 2000a) Deleted (CoE, 1992) |
Class I A3: Intake below threshold |
|
| 08.050 |
Hex‐3‐enoic acid 317 |
|
Category 1 (SCF, 1995) No safety concern (JECFA, 2000a) Category B (CoE, 1992) |
Class I A3: Intake below threshold |
|
| 08.058 |
2‐Methylpent‐3‐enoic acid 347 |
|
Category 1 (SCF, 1995) No safety concern (JECFA, 2000a) |
Class I A3: Intake below threshold |
|
| 08.064 |
(2E)‐Methylcrotonic acid 1205 |
|
No safety concern (JECFA, 2004b) FGE.72 |
Class I A3: Intake below threshold |
|
| 08.065 |
Dec‐9‐enoic acid 328 |
|
Category 1 (SCF, 1995) No safety concern (JECFA, 2000a) |
Class I A3: Intake below threshold |
|
| 08.070 |
3‐Methylcrotonic acid 1204 |
|
No safety concern (JECFA, 2004b) FGE.72 |
Class I A3: Intake below threshold |
|
| 08.072 | But‐2‐enoic acid (cis and trans) |
|
FGE.05 |
Class I A3: Intake below threshold |
|
| 08.073 |
Dec‐2‐enoic acid 1372 |
|
No safety concern (JECFA, 2005) FGE.71 |
Class I A3: Intake below threshold |
|
| 08.083 | Hept‐2‐enoic acid |
|
FGE.05 |
Class I A3: Intake below threshold |
|
| 08.107 |
(E)‐Pent‐2‐enoic acid 1804 |
|
No safety concern (JECFA, 2008) FGE.95 |
Class I A3: Intake below threshold |
|
| 08.114 |
2‐Octenoic acid 1805 |
|
No safety concern (JECFA, 2008) FGE.95 |
Class I A3: Intake below threshold |
|
| 08.119 | 2‐Hexenoic acid |
|
FGE.05 |
Class I A3: Intake below threshold |
FL‐no: FLAVIS number; JECFA: The Joint FAO/WHO Expert Committee on Food Additives; SCF: Scientific Committee on Food; CoE: Council of Europe; FGE: Flavouring Group Evaluation.
Category 1: Considered safe in use, Category 2: Temporarily considered safe in use, Category 3: Insufficient data to provide assurance of safety in use, Category 4: Not acceptable due to evidence of toxicity, Category N: Cannot be listed in cat. 1‐4 due to e.g. not used in the EU, not considered to be a flavour.
Category A: Flavouring substance, which may be used in foodstuffs, Category B: Flavouring substance which can be used provisionally in foodstuffs.