Figure 2.

Unadjusted and adjusted absolute differences in survival to hospital admission, survival to hospital discharge and functional status (modified Rankin Scale ≤3) at hospital discharge. The left side of the figure describes the unadjusted percentages of patients who achieved the described endpoints. The forest plot and numerical values on the right of each figure depict the adjusted absolute differences (with 95% confidence intervals) in the described endpoints. The upper forest plot depicts outcomes comparing IV amiodarone vs placebo and IO amiodarone vs placebo. The lower plot depicts outcomes comparing IV lidocaine vs placebo and IO lidocaine vs placebo. Significant differences in survival to hospital admission, to hospital discharge and favoring improved functional status at hospital discharge were observed in association with IV administration of amiodarone and lidocaine compared to placebo, but not when these drugs were administered IO. A statistically significant interation between the route of drug administration and outcome was not found.