TABLE 2.
Quantitative comparison of receptor profile among brexpiprazole, aripiprazole, paliperidone, and olanzapine
| DRUG | D2L/5-HT1A | D2L/5-HT2A | D2L/5-HT2C | D2L/α1A | D2L/M3 |
|---|---|---|---|---|---|
| Brexpiprazole (Ki/Ki) | 2.500 | 0.638 | 0.025 | 0.079 | NR |
| Aripiprazole (Ki/Ki) | 0.428 | 0.120 | 0.041 | 0.004 | 0.00015 |
| Paliperidone (Ki/Ki) | 0.035 | 30.245 | 0.913 | 1.203 | 0.00025 |
| Olanzapine (Ki/Ki) | 0.014 | 16.212 | 5.501 | 0.955 | 0.63127 |
The Ki for D2L receptor/Ki for each receptor ratio indicates the affinity of each receptor as a standard with dopamine D2L. D2L: dopamine-2 long isoform receptor; 5-HT1A: serotonin-1A, receptor; 5-HT2A: serotonin-2A receptor; 5-HT2C: serotonin-2C receptor; α1A: alpha-1A receptor; M3: muscarinic-3 receptor; NR: not reported