Table 3.
PrP reduced sequence matrix describing the eleven sites that are significantly different between susceptible (S), and resistant (R) species to CWD oral inoculation, site numbers refer to human PrP. Amino acid sites that were in the top 10% of loadings in the principle component analysis are highlighted in grey. Species/sequences that have not been exposed to CWD orally are indicated as of unknown status (U). Deletions are indicated by “-“.
| Amino acid site | 15 | 97 | 170 | 174 | 203 | 205 | 215 | 232 | 237 | 246 | 249 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Significance value (p) | 0.011 | 0.011 | 0.011 | 0.002 | 0.011 | 0.017 | 0.017 | 0.011 | 0.017 | 0.017 | 0.017 |
| Djungarian hamster (R) | A | N | N | N | V | M | I | A | S | F | F |
| Bovine, Bison01 (R) | M | G | S | N | I | M | I | - | S | F | F |
| Cat, ferret, mink, coyote, raccoon (R) | T | G | S | N | M | I | V | A | P | L | L |
| Coyote (R) | T | S | S | N | M | I | V | A | P | L | L |
| Squirrel monkey (S) & macaques (R) | T | N | S | N | V | M | I | M | S | F | F |
| Cervids (S) | M | S | N | T | I | M | I | - | S | F | F |
| Human (R) | T | S | S | N | V | M | I | M | S | F | F |
| Moose100R (U) | M | R | N | T | I | M | I | - | S | F | F |
| Bighorn, mountain goat (U) | M | S | S | N | I | I | I | - | S | F | F |
| Bison02 (U) | T | G | S | N | I | M | I | - | S | F | F |
| Pronghorn (U) | M | S | S | T | I | M | I | - | S | F | F |