Table B.1.

Summary of safety evaluation of the JECFA substances in the present group (JECFA, 2000, 2004, 2007)

FL‐no JECFA‐no	EU Register name	Structural formula	EU MSDIa US MSDI (μg/capita per day)	Classb Evaluation procedure pathc	Outcome on the named compound (d or e)	EFSA conclusion on the named compound (genotoxicity)
02.174 1617	2‐Methylbut‐2‐en‐1‐ol		0.037	Class I A3: Intake below threshold	d	Evaluated in FGE.201Rev2 as of no genotoxicity concern. The substance can be evaluated through the Procedure
05.033 1216	2‐Ethylhept‐2‐enal		0.012 0.1	Class I A3: Intake below threshold	d	Evaluated in FGE.201Rev2 as of no genotoxicity concern. The substance can be evaluated through the Procedure
05.090 1209	2‐Methylpent‐2‐enal		3.4 0.2	Class I A3: Intake below threshold	d	Evaluated in FGE.201Rev2 as of no genotoxicity concern. The substance can be evaluated through the Procedure
05.095 1201	2‐Methylcrotonaldehyde		0.61 0.2	Class I A3: Intake below threshold	d	Evaluated in FGE.201Rev2 as of no genotoxicity concern. The substance can be evaluated through the Procedure
05.105 1214	2‐Butylbut‐2‐enal		0.0 0.01	Class I A3: Intake below threshold	d	Evaluated in FGE.201Rev2 as of no genotoxicity concern. The substance can be evaluated through the Procedure
05.107 1215	2‐Isopropyl‐5‐methylhex‐2‐enal		0.24 0.01	Class I A3: Intake below threshold	d	Evaluated in FGE.201Rev2 as of no genotoxicity concern. The substance can be evaluated through the Procedure
05.126 1217	2‐Methyloct‐2‐enal		0.0 7.9	Class I A3: Intake below threshold	d	Evaluated in FGE.201Rev2 as of no genotoxicity concern. The substance can be evaluated through the Procedure
05.130	alpha‐Sinensal			Not evaluated by JECFA		Substance not in the Register
05.178 1227	beta‐Sinensal		0.91 0.5	Class I A3: Intake below threshold	d	Substance not supported by industry
07.261	4‐Methyl‐3‐hepten‐5‐one		–	Not evaluated by JECFA		Evaluated in FGE.201Rev2 as of no genotoxicity concern. The substance can be evaluated through the Procedure
09.177 1207	2‐Methylallyl butyrate		ND 0.2	Class I A3: Intake below threshold	d	Substance not supported by industry
09.931 1226	2,6‐Dimethyl‐2,5,7‐octariene‐1‐ol acetate		1.2 7.7	Class I A3: Intake below threshold	d	Evaluated in FGE.207, as of no genotoxicity concern and evaluated through the Procedure in FGE.72Rev1
12.065 471	2,8‐Dithianon‐4‐en‐4‐carboxaldehyde		0.012 0.1	Class I JECFA evaluated at step B5: intake below 1.5 μg/person per day	d	Evaluated in FGE.201Rev2 as of no genotoxicity concern. The substance can be evaluated through the Procedure
12.079 470	2‐(Methylthiomethyl)but‐2‐enal		0.024 0.1	Class I JECFA evaluated at step B5: intake below 1.5 μg/person per day	d	Evaluated in FGE.201Rev2 as of no genotoxicity concern. The substance can be evaluated through the Procedure

ND: not determined; JECFA: The Joint FAO/WHO Expert Committee on Food Additives; FL‐no: FLAVIS number; MSDI: maximised survey‐derived daily intake; FGE: Flavouring Group Evaluation.

^aEU MSDI: Amount added to food as flavour in (kg/year) × 10E⁹/(0.1 × population in Europe (= 375 × 10E⁶) × 0.6 × 365) = μg/capita per day.

^bThresholds of concern: Class I = 1,800 μg/person/day, Class II = 540 μg/person/day, Class III = 90 μg/person per day.

^cProcedure path A substances can be predicted to be metabolised to innocuous products. Procedure path B substances cannot.

^dNo safety concern based on intake calculated by the MSDI approach of the named compound.

^eData must be available on the substance or closely related substances to perform a safety evaluation.