Modification of the existing maximum residue levels for mandestrobin in apricots, cherries, peaches/nectarines and plums

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. 2018 Jan 20;16(1):e05148. doi: 10.2903/j.efsa.2018.5148

Commodity	Region/ Indoor^a	Residue levels observed in the supervised residue trials (mg/kg)^b	Comments/Source	Calculated MRL (mg/kg)	HR^b (mg/kg)	STMR^c (mg/kg)	CF^d
Apricots, peaches/nectarines	SEU	Apricots Mo: 0.11, 0.25, 0.35^e, 0.48, 1.1^e RA: 0.14, 0.28, 0.39^e, 0.51, 1.13^e Peaches Mo: 0.41, 0.51, 0.64, 0.83, 1.2 RA: 0.44, 0.54, 0.67, 0.86, 1.23	Residue trials compliant with the GAP for applications at BBCH growth stages 77–87 only. The trials on apricot and peach were combined to derive a common MRL for apricots and peaches/nectarines. The metabolite 4‐OH‐S‐2200 was present at levels at or above the LOQ of 0.01 mg/kg in one trial on apricot (at all five PHIs) and below the LOQ in all other trials. Metabolites 2‐CH₂OH‐S‐2200 and De‐Xy‐S‐2200 were below the LOQs of 0.01 mg/kg in all trials on apricot and peach.	2	Mo: 1.20 RA: 1.23	Mo: 0.50 RA: 0.53	1.13
Cherries	SEU	Mo: 0.38, 0.45, 0.52, 1.1, 1.4 RA: 0.41, 0.49, 0.58, 1.16, 1.43	Residue trials compliant with the GAP for applications at BBCH growth stages 77–87 only. The metabolite 4‐OH‐S‐2200 was present at levels at or above the LOQ of 0.01 mg/kg in all trials. Metabolite De‐Xy‐S‐2200 was present at the level of the LOQ of 0.01 mg/kg in samples from two trials (at four distinct PHIs) and below the LOQ in all other trials. Metabolite 2‐CH₂OH‐S‐2200 was below the LOQ of 0.01 mg/kg in all trials.	3	Mo: 1.40 RA: 1.43	Mo: 0.52 RA: 0.58	1.09
Plums	SEU	Mo: 0.06, 0.07, 0.07^e, 0.08, 0.09, 0.11^e, 0.17, 0.20, 0.20, 0.29^e ^, ^f RA: 0.09, 0.10, 0.10^e, 0.11, 0.12, 0.14^e, 0.20, 0.23, 0.23, 0.32^e ^, ^f	Residue trials compliant with the GAP for applications at BBCH growth stages 77–87 only. The metabolite 4‐OH‐S‐2200 was present at levels at or above the LOQ of 0.01 mg/kg in one trial (at two PHIs) and below the LOQ in all other trials. Metabolites 2‐CH₂OH‐S‐2200 and De‐Xy‐S‐2200 were below the LOQs of 0.01 mg/kg in all trials.	0.5	Mo: 0.29 RA: 0.32	Mo: 0.10 RA: 0.13	1.40

Commodity

Region/

Indoor^a

Residue levels observed in the supervised residue trials (mg/kg)^b

Comments/Source

Calculated MRL (mg/kg)

HR^b (mg/kg)

STMR^c (mg/kg)

CF^d

Apricots, peaches/nectarines

SEU

Apricots

Mo: 0.11, 0.25, 0.35^e, 0.48, 1.1^e

RA: 0.14, 0.28, 0.39^e, 0.51, 1.13^e

Peaches

Mo: 0.41, 0.51, 0.64, 0.83, 1.2

RA: 0.44, 0.54, 0.67, 0.86, 1.23

Residue trials compliant with the GAP for applications at BBCH growth stages 77–87 only. The trials on apricot and peach were combined to derive a common MRL for apricots and peaches/nectarines. The metabolite 4‐OH‐S‐2200 was present at levels at or above the LOQ of 0.01 mg/kg in one trial on apricot (at all five PHIs) and below the LOQ in all other trials. Metabolites 2‐CH₂OH‐S‐2200 and De‐Xy‐S‐2200 were below the LOQs of 0.01 mg/kg in all trials on apricot and peach.

Mo: 1.20 RA: 1.23

Mo: 0.50 RA: 0.53

1.13

Cherries

SEU

Mo: 0.38, 0.45, 0.52, 1.1, 1.4

RA: 0.41, 0.49, 0.58, 1.16, 1.43

Residue trials compliant with the GAP for applications at BBCH growth stages 77–87 only. The metabolite 4‐OH‐S‐2200 was present at levels at or above the LOQ of 0.01 mg/kg in all trials. Metabolite De‐Xy‐S‐2200 was present at the level of the LOQ of 0.01 mg/kg in samples from two trials (at four distinct PHIs) and below the LOQ in all other trials. Metabolite 2‐CH₂OH‐S‐2200 was below the LOQ of 0.01 mg/kg in all trials.

Mo: 1.40

RA: 1.43

Mo: 0.52

RA: 0.58

1.09

Plums

SEU

Mo: 0.06, 0.07, 0.07^e, 0.08, 0.09, 0.11^e, 0.17, 0.20, 0.20, 0.29^e ^, ^f

RA: 0.09, 0.10, 0.10^e, 0.11, 0.12, 0.14^e, 0.20, 0.23, 0.23, 0.32^e ^, ^f

Residue trials compliant with the GAP for applications at BBCH growth stages 77–87 only. The metabolite 4‐OH‐S‐2200 was present at levels at or above the LOQ of 0.01 mg/kg in one trial (at two PHIs) and below the LOQ in all other trials. Metabolites 2‐CH₂OH‐S‐2200 and De‐Xy‐S‐2200 were below the LOQs of 0.01 mg/kg in all trials.

0.5

Mo: 0.29

RA: 0.32

Mo: 0.10

RA: 0.13

1.40

NEU: Outdoor trials conducted in northern Europe; SEU: Outdoor trials conducted in southern Europe; Indoor: indoor EU trials or Country code: if non‐EU trials.

Highest residue. The highest residue for risk assessment refers to the whole commodity and not to the edible portion.

Supervised trials median residue. The median residue for risk assessment refers to the whole commodity and not to the edible portion.

CF: Conversion factor to recalculate residues according to the residue definition for monitoring to the residue definition for risk assessment.

Peak residue detected after the GAP minimum PHI.

Value identified as an outlier according to Dixon test but included in the MRL and risk assessment calculations since no further explanation is given in study reports.