Table 8.
Summarised data on adverse effects in broiler chickens exposed to DAS in feed from studies considered for further risk assessment
| Species (age) | No. per treatment | Concentration (mg/kg feed) | Toxin source in feed | Exposure time | Adverse effects | LOAEL (mg/kg feed) | NOAEL (mg/kg feed) | Reference |
|---|---|---|---|---|---|---|---|---|
| Hubbard × Hubbard (day 1) | 10 | 15, 18, 21 | Spiked with purified DAS | 10 days | Mortalities, reduction bw gain, hepatic lesions | 15 | Hoerr et al. (1982a) | |
| Hubbard × Hubbard (day 1) | 10 | 4, 16 | Spiked with purified DAS | 21 days | Reduction bw gain oral lesions |
4 4 |
Hoerr et al. (1982b) | |
| Arbor Acres × Arbor Acres (day 1) | 30 | 0.5, 1, 2, 4 | Spiked with pure DAS | 21 days | Reduction bw gain oral lesions |
2 1 |
1 0.5 |
Ademoyero and Hamilton (1991a) |
| Peterson × Hubbard (day 1) | 10 | 5 | Spiked with purified DAS | 8 days | Reduction bw gain | 5 | Kubena et al. (1993) | |
| Petersons × Hubbard (day 1) | 10 | 6 | Spiked with purified DAS | 19 days | Reduction bw gain oral lesions |
6 6 |
Kubena et al. (1994) | |
| Broiler breeders Male female (day 25) |
10 25 |
5, 10, 20 | Purified | 2 weeks |
Decreased male fertility Decreased female bw Decreased male bw oral lesions in males and females |
10 10 5 |
5 5 10 |
Brake et al. (1999, 2000) |
| Male Ross (day 1) | 10 | 0.2, 0.5, 1 | Pure | 35 days |
Oral lesions for half of the birds Reduction of bw gain |
0.2 | 1 | Sklan et al. (2001) |
| Male Ross (day 1) | 7 | 1, 2 | Purified | 3 weeks | Oral lesions and reduction of bw gain | 1 | Diaz (2002) |
DAS: diacetoxyscirpenol; LOAEL: lowest‐observed‐adverse‐effect level; NOAEL: no‐observed‐adverse‐effect level; bw: body weight.