Table 2.

Linear mixed effect models showing the moderating effects of striatal prediction error signals on symptom improvement across the 6 weeks of treatment

Model term a	Coefficient	SE	Z	P
Model 1: Ventral striatal gain prediction error predicts change in global illness severity
Week	−0.26	0.04	−6.59	<0.001
Ventral striatal gain prediction error	0.34	0.12	2.96	0.003
Week × Ventral striatal gain prediction error	−0.08	0.03	−2.87	0.004
Model 2: Ventral striatal loss prediction error predicts change in anhedonia
Baseline SHAPS	0.82	0.17	4.79	<0.001
Week	−0.77	0.31	−2.50	0.012
Ventral striatal loss prediction error	−1.52	0.91	−1.67	0.095
Week × Ventral striatal loss prediction error	0.61	0.21	2.91	0.004

^aThe CGI-Change Scale measures changes in global illness severity and was therefore first administered after 1 week of treatment. Accordingly, models do not include a baseline CGI score term.