Table 9.
Case reports of myopathy and rhabdomyolysis associated with intake of food supplements containing monacolin K from RYR preparations, published in the scientific literature
| Patient data | Daily intake of monacolin K | Period of intake | Adverse effects | Reference |
|---|---|---|---|---|
| Female, 52 years old | 2.6 mg | 90 days | Increase level of serum CK; Myalgia | Philibert et al. (2016) |
| Female, 53 years old | 3 mg | 60 days | Increased level of serum CK | Lapi et al. (2008) |
| Sex unknown, 48 years old | 3 mg | 60 days | Rhabdomyolysis (hospitalisation) | Mazzanti et al. (2017) |
| Female, 45 years old | 3 mg | 24 days | Nocturnal leg muscle cramps | Mazzanti et al. (2017) |
| Female, 45 years old | 3 mg | 54 days | Myalgia in the leg | Mazzanti et al. (2017) |
| Female, 53 years old | 3 mg | 97 days | Generalised muscle aches | Mazzanti et al. (2017) |
| Female, 57 years old | 3 mg | 60 days | Increased level of serum CK (10 times). | Mazzanti et al. (2017) |
| Female, 65 years old | 3 mg | 31 days | Cramps and myalgia of lower extremities | Mazzanti et al. (2017) |
| Female, 67 years old | 3 mg | 31 days | Increased level of serum CK, myopathy, asthenia. Previous myopathy by statins | Mazzanti et al. (2017) |
| Female, 68 years old | 3 mg | 62 days | Localised muscle pain; increased level of serum CK | Mazzanti et al. (2017) |
| Female, 69 years old | 3 mg | 25 days | Myalgia of lower extremities | Mazzanti et al. (2017) |
| Female, 70 years old | 3 mg | 90 days | Myalgia, increased level of serum CK, Previous statin intolerance | Mazzanti et al. (2017) |
| Female, age unknown | 3 mg | > 365 days | Increased level of serum CK, previously observed with statins | Mazzanti et al. (2017) |
| Male, 60 years old | 3 mg | 165 days | Increased level of serum CK | Mazzanti et al. (2017) |
| Female, | 4–8 mg | 4 months | Myalgia | Venhuis et al. (2016) |
| Male, 49 years old | 5 mg | 60 days | Increased level of serum CK | Lapi et al. (2008) |
| Female, 64 years old | 10.2 mg | 30 days | Increase level of serum CK | Philibert et al. (2016) |
| Female, 51 years old | 19.8 mg | 30 days | Myalgia | Philibert et al. (2016) |
| Male, 37 years old | 19.2 mg | 48 days | Rhabdomyolysis, increased level of serum CK | Philibert et al. (2016) |
| Female, 51 years old | 19.8 mg | 30 days | Myalgia | Philibert et al. (2016) |
CK: creatine kinase.