Figure 4.

Ontology analysis of top predictor genes of LOAD development. Significant molecular functions (A–C), cell types (D) and molecular pathways (E) identified in the brain’s prefrontal cortex (PFC) (ROSMAP) and BA9 (HBTRC) areas, and the blood plasma (ADNI). (A–C) Bars show the number of genes associated to the main GO over-represented categories. In E, only common pathways identified across the three populations are shown (for complete lists of genes and pathways, see Supplementary Tables 2–5). The colour scale indicates the presence level (in %) of each functional pathway (e.g. dark blue for absent pathways, red for highly represented pathways).