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. 2020 Jan 22;143(2):597–610. doi: 10.1093/brain/awz413

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Mendelian randomization associations of genetic determinants of cholesterol (C) and triglyceride (TG) concentrations in size-defined lipoprotein particles with risk of small vessel stroke and WMH volume. Shown are the results derived from random-effects inverse-variance weighted (IVW) Mendelian randomization and multivariable Mendelian randomization (MVMR) analyses. MVMR for cholesterol in HDL particles adjusted for LDL-C and triglycerides; for cholesterol in LDL and larger particles adjusted for HDL-C and triglycerides; and for triglycerides in any particles adjusted for HDL-C and LDL-C. IDL = intermediate density lipoprotein; L = large; M = medium; S = small; VLDL = very low density lipoprotein; XL = extra-large.