Table A.1.
Summary of data used for derivation of benchmark doses for megalocytic hepatocytes and hepatic apoptosis (Bondy et al., 2012)
| Doses in mg/kg bw per day | Individual scores megalocytic hepatocytes (cut off = 1) | Combined incidence megalocytic hepatocytes (WT and TG) | Individual scores Apoptosis (cut off = 2) | Combined incidence apoptosis (WT and TG) |
|---|---|---|---|---|
|
0 (WT) 0 (TG) |
0 0 0 0 0 0 0 0 0 (WT) 0 0 0 0 0 0 0 0 0 0 (TG) |
0/19 |
1 1 1 1 1 1 1 1 1 (WT) 1 1 1 1 1 1 1 1 1 1 (TG) |
0/19 |
|
0.39 (WT) 0.37 (TG) |
0 0 0 0 0 0 1 0 2 0 (WT) 0 0 1 0 0 0 0 0 1 0 (TG) |
4/20 |
1 1 1 1 1 1 1 1 1 1 (WT) 1 1 1 1 1 1 1 1 1 1 (TG) |
0/20 |
|
3.87 (WT) 3.88 (TG) |
1 0 2 1 0 0 1 0 1 (WT) 2 2 2 0 0 0 0 1 0 0 (TG) |
9/19 |
4 3 4 4 2 2 2 1 3 (WT) 4 3 4 3 3 5 1 2 4 3 (TG) |
17/19 |
|
12.2 (WT) 12.6 (TG) |
5 5 5 5 4 3 3 5 5 5 (WT) 5 5 5 5 5 5 5 0 5 5 (TG) |
19/20 |
4 4 4 5 5 5 3 4 5 5 (WT) 4 3 3 4 4 4 4 3 5 5 (TG) |
20/20 |
WT: WG strain; TG: TG strain.
Note: for explanation of pathology scoring see Section 10.2.7.