| Medicine (INN) | Dose (p.o.) infants > 4 months up to children 3 years old (mg/kg bw per day) | Dose (p.o.) adult (mg/kg bw per day) | Ratio adult/infant (value > 1 indicates that infant is more sensitive) |
|---|---|---|---|
| Weight (used for calculation) | 10 kg | 70 kg | 7 |
| Acetycystein | 10–15 | 8.6 | 0.715 |
| Acetylsalicylic acid | 30–45 | 21.4–42.8 | 0.95 |
| Albendazol | 15 | 11.4 | 0.76 |
| Amlodipine | 0.05 | 0.07–0.14 | 1.2 |
| Amoxicillin | 24–48 | 21.4–28.6 | 0.7 |
| Azithromycin | 10 | 7.14 | 0.714 |
| Captopril | 2 | 6 | 3 |
| Carbamazepine | 35 | 22.8 | 0.65 |
| Carvedilol | 0.05 | 0.178 | 3.6 |
| Cefaclor | 40 | 42.85 | 1.1 |
| Cefadroxil | 100 | 57.1 | 0.57 |
| Cefazolin | 100 | 171 | 1.7 |
| Cefepim | 150 | 85 | 0.57 |
| Cefixim | 8–12 | 5.7 | 0.7 |
| Cefpodoxime | 8–10 | 11.4 | 1.1 |
| Cefuroxime | 20–30 | 14.3 | 0.57 |
| Cephalexin | 40 | 42.85 | 1.1 |
| Chloroquine | 25–30 | 25–30 | 1 |
| Cimetidine | 15–30 | 28.5 | 0.95 |
| Clarithromycin | 15 | 14.3 | 0.95 |
| Clindamycin | 30 | 25.7 | 0.86 |
| Clobazam | 0.5–1 | 1.14 | 1.5 |
| Clonidine | 0.025 | 0.01285 | 0.5 |
| Desloratadine | 0.1 | 0.07 | 0.7 |
| Diclofenac | 1–3 | 1.4–2.8 | 1 |
| Digoxin | 0.01 | 0.0036 | 0.36 |
| Dimenhydrinate | 5 | 5.7 | 1.1 |
| Dimetindenmaleat | 0.15–0.225 | 0.08 | 0.53 |
| Doxylamine succinate | 0.625–1.25 | 0.35–0.7 | 0.57 |
| Enalapril | 0.5 | 0.6 | 1.1 |
| Ethosuximide | 15–40 | 14.3 | 0.5 |
| Flucloxacillin | 40–50 | 171.4 | 3.8 |
| Fluconazol | 6–12 | 5.7 | 0.63 |
| Fluconazole | 3–12 | 5.7 | 0.76 |
| Fosfomycin | 100–300 | 285 | 1.43 |
| Furosemid | 1–2 | 1.7 | 1.1 |
| Hydrochlorothiazide | 1–3 | 1.42 | 0.71 |
| Ibuprofen | 30–60 | 45.7 | 1.01 |
| Isoniacid | 8–10 | 8 | 0.9 |
| Ketotifen | 0.1 | 0.11 | 1.1 |
| Lacosamide | 10 | 8.6 | 0.86 |
| Levetiracetam | 20–60 | 42.9 | 1.1 |
| Linezolid | 30 | 17.1 | 0.58 |
| Loracarbef | 15–30 | 11.4 | 0.5 |
| Lorazepam | 0.4 | 0.14 | 0.36 |
| Meropenem | 30–60 | 42 | 0.95 |
| Metamizol | 32–64 | 57.1 | 1.2 |
| Metildogoxin | 0.008 | 0.004 | 0.5 |
| Metolazone | 0.2–0.4 | 0.07–0.14 | 0.36 |
| Metronidazol | 20–30 | 28 | 1.14 |
| Morphin | 1.8 | 1.8 | 1 |
| Naproxen | 15 | 17.85 | 1.2 |
| Neostigminmethylsulfat | 0.6 | 0.14 | 0.23 |
| Niclosamid | 25 | 14.2 | 0.57 |
| Nitrofurantoin | 5 | 5 | 1 |
| Omeprazol | 3.5 | 1.7 | 0.5 |
| Oxacillin | 80–160 | 171 | 1.43 |
| Paracetamol | 40–60 | 40–60 | 1 |
| Penicillin V | 15–63 | 50.6 | 2.1 |
| Pethidin | 3–12 | 2.1–12.8 | 1 |
| Phenobarbital | 5–10 | 1–3 | 0.27 |
| Pipamperon | 2‐4‐6 | 1.7–5.1 | 1 |
| Propafenon | 10–20 | 12.8 | 0.96 |
| Propiverin | 0.7–0.9 | 0.21–0.63 | 0.52 |
| Propranolol | 8 | 4.6 | 0.57 |
| Ranitidin | 4–8 | 4.3–12.9 | 1.6 |
| Rifampicin | 15 | 17 | 1.1 |
| Roxithromycin | 5–7.5 | 4.3 | 0.7 |
| Spironolactone | 1–3 | 1.4–2.8 | 1.15 |
| Sulfamethazol | 60 | 34.3 | 0.57 |
| Sultamicillin | 50 | 21.4 | 0.43 |
| Sultiam | 5–10 | 5–10 | 1 |
| Terbutalin | 0.15–0.45 | 0.21 | 0.7 |
| Theophyllin | 18 | 13 | 0.7 |
| Topiramate | 5–9 | 7.14 | 1.0 |
| Tramadol | 12 | 8.6 | 0.7 |
| Trimethoprim | 12 | 6.8 | 0.57 |
| Ursodesoxycholic acid | 10–15 | 10–15 | 1 |
| Valproic acid | 30–60 | 14.3–35.7 | 0.56 |
| Vancomycin | 40 | 28.6 | 0.7 |
| Verapamil | 4 | 6.8 | 1.7 |
| Vigabatrin | 40 | 14.3 | 0.35 |
| Mean value (n = 82) | 0.95 | ||
| SD | 0.61 | ||
| Range | 0.23–3.8 | ||
Information extracted from:
MacPeds Formulary, a document used in McMaster Children's Hospital (MCH), McMaster and St Joseph's Healthcare, Canada.
Medicine Base, Wissenschaftliche Verlagsgesellschaft, Stuttgart, Germany. www.drugbase.de last accessed 09 January 2018.