Table 4.
Unadjusted models by PART versus Alzheimer’s disease in participants with MCI (CDR = 0.5) at baseline
| Score | Number of participant visits | Annual rate of change (unadjusted) a | Annual difference between PART and AD b | ||
|---|---|---|---|---|---|
| PART | AD | ||||
| β est (95% CI) | β est (95% CI) | β est (95% CI) | P-value | ||
| CDR-SB | 2798 | 0.71 (0.49, 0.93) | 1.81 (1.63, 1.99) | 1.10 (0.89, 1.31) | <0.001 |
| Global composite | 1437 | −0.11 (−0.15, −0.08) | −0.25 (−0.28, −0.22) | −0.13 (−0.17, −0.10) | <0.001 |
| Episodic memory | 1989 | −0.07 (−0.12, −0.01) | −0.19 (−0.23, −0.16) | −0.13 (−0.19, −0.06) | <0.001 |
| Attention/working memory | 2058 | −0.06 (−0.10, −0.03) | −0.17 (−0.19, −0.15) | −0.11 (−0.14, −0.07) | <0.001 |
| Executive function | 1500 | −0.20 (−0.26, −0.14) | −0.39 (−0.42, −0.35) | −0.19 (−0.25, −0.12) | <0.001 |
| Semantic memory/language | 1991 | −0.13 (−0.16, −0.10) | −0.34 (−0.38, −0.30) | −0.21 (−0.26, −0.16) | <0.001 |
a
Interpretation: a negative β estimate and a 95% CI that does not include zero indicates significant decline with the exception of CDR-SB, where a positive β estimate and a 95% CI that does not include zero indicates significant decline.
b
Interpretation: a negative difference indicates PART is declining at a slower rate than Alzheimer’s disease except for CDR-SB where a positive difference indicates PART is declining at a slower rate than Alzheimer’s disease.
AD = Alzheimer’s disease; CI = confidence interval.