Table E.2.

Additional genotoxicity data (in vivo) considered by the Panel in FGE.203Rev1

Register name [FL‐no]	Test system in vivo	Test object	Route	Dose	Result	Reference	Comments
Deca‐2(trans),4(trans)‐dienal [05.140]	Micronucleus induction	Male rat bone marrow polychromatic erythrocytes	i.p.	100, 200, 400 and 600 mg/kg bw	Positivea	NTP (2011)	Study design complies with OECD Guideline 474
		Male mouse bone marrow polychromatic erythrocytes	i.p.	25, 50, 100 and 200 mg/kg bw	Equivocalb		A trend of increase but not statistically significant. Study design complies with OECD Guideline 474
		Male mouse bone marrow polychromatic erythrocytes	i.p.	400 and 600 mg/kg bw	Positivea		Significant increase only at the highest dose. Study design complies with OECD Guideline 474
		Male mouse peripheral blood polychromatic erythrocytes	i.p.	400 and 600 mg/kg bw	Negativea		No statistically significant increase of micronucleated cells was observed. Study design complies with OECD Guideline 474
		Mouse peripheral blood reticulocytes	gavage	50, 100, 200, 400 and 800 mg/kg bw per day	Negativec		No statistically significant increase of micronucleated cells was observed. Study design complies with OECD Guideline 474

bw: body weight; OECD: Organisation for Economic Co‐operation and Development.

^aAdministered as a single intraperitoneal injection.

^bAdministered 3x by intraperitoneal injection at 24‐h intervals.

^cAdministered by gavage for a period of 14 weeks.