Figure 7.

Overview about toxicokinetics, damage dynamics and survival models (stochastic death (SD) and individual tolerance (IT)) as used in the GUTS TKTD model framework. In the top panel, two formulations of the damage dynamics and the respective model equations are given. The bottom panel shows the two formulations of the death mechanism (SD and IT) together with the model equations. Parameters that must be determined from experimental data are marked in blue and explained in Chapter 2 and the following text. Combination of damage dynamics and death mechanism result in possible GUTS‐RED‐SD, GUTS‐RED‐IT, GUTS‐SD and GUTS‐IT models, which are defined by the given equations. Calibration of model parameters is explained in Section 4.1.3