Dw
|
Scaled damage, referenced to external concentration |
mol/L |
Di
|
Scaled damage, referenced to internal concentration |
mol/kg |
Cw
|
External chemical concentration in the environment |
mol/L |
Ci
|
Internal chemical concentration in an organism |
mol/L |
kD
|
Dominant rate constant for the reduced model |
day−1 (or time−1) |
kin
|
Uptake rate constant for chemicals into the body |
L/kg d−1
|
kout
|
Elimination rate constant for chemicals from the body |
day−1
|
kR
|
Damage repair rate constant |
day−1
|
h |
Cumulative hazard rate |
day−1
|
b |
Killing rate constant |
[D]/day−1
|
bi
|
Killing rate constant referenced to internal concentration |
kg/mol d−1
|
bw
|
Killing rate constant referenced to external concentration |
L/mol d−1 (or time−1) |
z |
Threshold for effects |
[D] |
zi
|
Threshold for effects referenced to internal concentration |
mol/kg |
zw
|
Threshold for effects referenced to external concentration |
mol/L |
hb
|
Background hazard rate |
day−1
|
mi
|
Median of the distribution of thresholds, ref. to internal conc. |
mol/kg |
mw
|
Median of the distribution of thresholds, ref. to external conc. |
mol/L |
β |
Shape parameter for the distribution of thresholds |
[−] |