Table 3.
Dose–response analysis of critical haematological endpoints HCT and Hb in pigs based on the combined data from two experiments of Harvey et al. (2001) using the PROAST software for the BMD approach
| Best fitting model | HCT | ||
|---|---|---|---|
| BMD 05 | BMDL 05 –BMDU 05 | ||
| mg/kg bw per day | |||
| Experiment 1 | |||
| Exponential model family | E5 | 1.14 | 0.55–2.05 |
| Hill model family | H5 | 1.30 | 0.59–2.01 |
| Experiment 2 | |||
| Exponential model family | E5 | 0.50 | 0.23–1.04 |
| Hill model family | H5 | 0.59 | 0.25–1.00 |
| Best fitting model | Hb | ||
|---|---|---|---|
| BMD05 | BMDL05–BMDU05 | ||
| mg/kg bw per day | |||
| Experiment 1 | |||
| Exponential model family | E5 | 0.92 | 0.45–1.56 |
| Hill model family | H5 | 0.97 | 0.45–1.79 |
| Experiment 2 | |||
| Exponential model family | E5 | 0.42 | 0.20–0.77 |
| Hill model family | H5 | 0.46 | 0.21–0.89 |
BMD05: benchmark dose response of 5%; BMDL05/BMDU05: 95% lower/upper confidence limit for the benchmark dose response of 5%; bw: body weight; HCT: haematocrit; Hb: haemoglobin.
Note: The two‐sided 90% confidence intervals (BMDL05–BMDU05) of the BMD05 of the best fitting models defined by the Akaike Information Criterion (AIC) are reported for the exponential and the Hill family following the EFSA guidance (EFSA Scientific Committee, 2017).