Table C.2.

Summary of dose–response analysis of acute toxicity data in female rats of Abbas et al. (1990)

Models	Number of parameters	Minus Log‐likelihood	p‐value	AIC	LD50	LDL50	Comment
					(mg/kg bw per day)
Full model	9	2.50	na	23.00	na	na
Null (reduced) model	1	31.09		64.18	na	na
Probit	2	2.50	1	9.00	18.71	14.09	Accepted
Logistic	2	2.50	1	9.00	19,32	14.09	Accepted
LogProbit	2	2.50	1	9.00	18.32	13.14	Accepted
LogLogistic	2	2.50	1	7.00	18.52	13.08	Accepted
Multistage							No fit
Multistage Cancer	1	4.57	0.85	11.14	16.54	11.69	Accepted
Quantal‐Linear	1	8.32	0.17	18.63	14.04	8.80	Not accepted
Weibull							No fit
Gamma							No fit

BMD₅₀: benchmark dose response of 50%; BMDL₅₀: 95% lower confidence limit for the benchmark dose response (BMR) of 50%; bw: body weight; na: not available, including cases where the BMD/Ls were not calculated, the fit was incomplete, or serious or conflicting comments were noted (e.g. parameters reaching boundaries).

Note: The models with the lowest AIC among the accepted models and the model with the lowest LDL₅₀ (corresponding to a BMDL₅₀) are in bold.