Table 2.
Groundwater
| Compound (name and/or code) | Mobility in soil | > 0.1 μg/L at 1 m depth for the representative usesa | Pesticidal activity | Toxicological relevance |
|---|---|---|---|---|
| Chlorothalonil |
Medium mobility to immobile KFoc 330–7,000 mL/g |
No | Yes | Yes |
| SDS‐3701 (R182281) |
Medium to low mobility KFoc 250–718 mL/g |
No | No data |
Yes Acutely toxic when ingested; Genotoxicity potential cannot be excluded in the absence of in vivo follow up to the positive and equivocal results in vitro gene mutation tests |
| R417888 |
Very high mobility KFoc 4.6–17.2 mL/g |
Yes Wheat‐barley: 9/9 FOCUS scenario (4.0–23.4 μg/L, bi‐annual application) Tomatoes: 5/5 FOCUS scenario (3.6–17.3 μg/L, annual application) Potatoes: 9/9 FOCUS scenario (1.8–9.4 μg/L, annual application) |
No |
Yes Genotoxic potential cannot be excluded regarding gene mutation and aneugenicity |
| R418503 |
Too low to measure – very high mobility KFoc 2.0–4.0 mL/g |
Yes Wheat‐barley: 8/9 FOCUS scenario (0.12–2.2 μg/L, bi‐annual application) Tomatoes: 5/5 FOCUS scenario (0.12–0.58 μg/L, annual application) Potatoes: 6/9 FOCUS scenario (0.11–1.14 μg/L, annual application) |
No |
Yes Based on the harmonised classification of the parent as Carc 2 and proposed classification of the peer review as Carc 1B; Unlikely to be genotoxic |
| R419492 | Too low to measure – Very high mobility |
Yes Wheat‐barley: 9/9 FOCUS scenario (7.7–45.0 μg/L, bi‐annual application) Tomatoes: 5/5 FOCUS scenario (6.1–24.8 μg/L, annual application) Potatoes: 9/9 FOCUS scenario (0.5–13.9 μg/L, annual application) |
No |
Yes Based on the harmonised classification of the parent as Carc 2 and proposed classification of the peer review as Carc 1B; Unlikely to be genotoxic |
| R471811 | Too low to measure – Very high mobility |
Yes Wheat‐barley: 9/9 FOCUS scenario (2.2–33.5 μg/L, bi‐annual application) Tomatoes: 5/5 FOCUS scenario (1.8–17.2 μg/L, annual application) Potatoes: 9/9 FOCUS scenario (0.9–8.5 μg/L, annual application) |
No |
Yes Based on the harmonised classification of the parent as Carc 2 and proposed classification of the peer review as Carc 1B; Unlikely to be genotoxic |
| SYN507900 |
Very high mobility KFoc 11.0–22.0 mL/g |
Yes Wheat‐barley: 9/9 FOCUS scenario (4.4–26.1 μg/L, bi‐annual application) Tomatoes: 5/5 FOCUS scenario (4.6–15.0 μg/L, annual application) Potatoes: 9/9 FOCUS scenario (2.3–8.4 μg/L, annual application) |
No |
Yes Based on the harmonised classification of the parent as Carc 2 and proposed classification of the peer review as Carc 1B; Unlikely to be genotoxic |
| R611965 |
Very high to high mobility KFoc 3.2‐77.0 mL/g |
Yes Wheat‐barley: 9/9 FOCUS scenario (3.4–22.1 μg/L, bi‐annual application) Tomatoes: 5/5 FOCUS scenario (3.0–14.8 μg/L, annual application) Potatoes: 9/9 FOCUS scenario (1.3–7.7 μg/L, annual application) |
No |
No (up to step 3 of stage 3) Unlikely to be genotoxic; of lower toxicity than chlorothalonil; does not share the same target organ as the parent (kidneys) responsible to the carcinogenic potential; ADI: 0.5 mg/kg bw per day ARfD: 0.83 mg/kg bw |
| R611966 |
Medium to low mobility KFoc 389–911 mL/g |
No | No data |
Yes Based on the harmonised classification of the parent as Carc 2 and proposed classification of the peer review as Carc 1B; No data on genotoxicity |
| R611967 |
Medium to low mobility KFoc 212–1121 mL/g |
No | No data |
Yes Based on the harmonised classification of the parent as Carc 2 and proposed classification of the peer review as Carc 1B; No data on genotoxicity |
| R613636 |
High to medium mobility KFoc 130–325 mL/g |
No | No |
Yes Based on the harmonised classification of the parent as Carc 2 and proposed classification of the peer review as Carc 1B; Genotoxic potential could not be excluded: aneugenicity has not been addressed |
| R611968 |
High mobility KFoc 51.0–128.0 mL/g |
Yes Wheat‐barley: 7/9 FOCUS scenario (0.14–0.66 μg/L, bi‐annual application) Tomatoes: 4/5 FOCUS scenario (0.14–0.27 μg/L, annual application) Potatoes: 6/9 FOCUS scenario (0.1–0.27 μg/L, annual application) |
No |
Yes Based on the harmonised classification of the parent as Carc 2 and proposed classification of the peer review as Carc 1B; Unlikely to be genotoxic |
| SYN548008 (M3) | Data gap |
Yes Wheat‐barley: 9/9 FOCUS scenario (1.2–79.2 μg/L, bi‐annual application) Tomatoes: 5/5 FOCUS scenario (1.4–22.4 μg/L, annual application) Potatoes: 9/9 FOCUS scenario (0.12–12.0 μg/L, annual application) |
No |
Yes Based on the harmonised classification of the parent as Carc 2 and proposed classification of the peer review as Carc 1B; Unlikely to be genotoxic |
| SYN548581 (M11) | Data gap |
Yes Wheat‐barley: 9/9 FOCUS scenario (3.6–21.0 μg/L, bi‐annual application) Tomatoes: 5/5 FOCUS scenario (3.1–14.2 μg/L, annual application) Potatoes: 9/9 FOCUS scenario (1.5–7.5 μg/L, annual application) |
No |
Yes Based on the harmonised classification of the parent as Carc 2 and proposed classification of the peer review as Carc 1B; No data on genotoxicity |
| M2 | Open |
Yes Wheat‐barley: 9/9 FOCUS scenario (2.4–8.5 μg/L, bi‐annual application) Tomatoes: 5/5 FOCUS scenario (1.9–5.7 μg/L, annual application) Potatoes: 9/9 FOCUS scenario (0.9–3.0 μg/L, annual application) |
No |
Yes Based on the harmonised classification of the parent as Carc 2 and proposed classification of the peer review as Carc 1B; |
| M7 | Open |
Yes Wheat‐barley: 9/9 FOCUS scenario (5.6–20.4 μg/L, bi‐annual application) Tomatoes: 5/5 FOCUS scenario (4.4–13.7 μg/L, annual application) Potatoes: 9/9 FOCUS scenario (2.0–7.2 μg/L, annual application) |
No |
Yes Based on the harmonised classification of the parent as Carc 2 and proposed classification of the peer review as Carc 1B; No data on genotoxicity |
| M10 | Open |
Yes Wheat‐barley: 9/9 FOCUS scenario (2.4–8.5 μg/L, bi‐annual application) Tomatoes: 5/5 FOCUS scenario (1.9–5.7 μg/L, annual application) Potatoes: 9/9 FOCUS scenario (0.9–3.0 μg/L, annual application) |
No |
Yes Based on the harmonised classification of the parent as Carc 2 and proposed classification of the peer review as Carc 1B; No data on genotoxicity |
KFoc: Freundlich organic carbon adsorption coefficient; FOCUS: Forum for the Co‐ordination of Pesticide Fate Models and their Use; ADI: acceptable daily intake; ARfD: acute reference dose; bw: body weight.
FOCUS scenarios or a relevant lysimeter.