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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Semin Cancer Biol. 2019 Jul 26;66:140–154. doi: 10.1016/j.semcancer.2019.07.013

Fig. 1. Schematic representation of MDA-7/IL-24 protein with predicted and established domains and protein modification sites indicated.

Fig. 1.

The IL-10 signature sequence is located between amino acid 101 and 121. N-glycosylation can occur at amino acid 85, 99 and 126. Protein kinase C consensus phosphorylation sites are present at amino acid 88, 133 and 161. Casein kinase II (CKII) consensus phosphorylation sites are present at amino acid 101, 111 and 161. Numbers indicate amino acids. Not drawn to scale. Cleavage of the 49-amino acid signal peptide allows for secretion of the MDA-7/IL-24 protein. (Figure reproduced from Menezes et al., 2014).