Table 1.
MDA-7/IL-24 as an anti-cancer gene in diverse cancers.
| Cancer indication | Preclinical model | Therapeutic agent | References |
|---|---|---|---|
| Breast cancer | Cells/mouse model | Ad.mda-7 (12), transgenic mouse model (68, 69), Ad.mda-7 and purified MDA-7/IL-24 protein (70) | 11, 73–75 |
| Prostate cancer | Cells/mouse model | MB-Ad.mda-7; MB-CTV :UTMD approach (71), Ad.mda-7 (72), Ad.5/3-mda-7 (73) | 76–78 |
| Lung cancer | Cells/mouse model | VV-IL-24 (74), Ad.mda-7; expression plasmid carrying the mda-7 (75) | 79, 80 |
| Melanoma | Cells/mouse model | Ad.mda-7 (76), purified MDA-7/IL-24 protein (77), purified MDA-7/IL-24 protein (78) | 81–83 |
| Malignant glioma | Cells/mouse model | Ad.mda-7 or GST-MDA-7 as single agent and in combination with radiation (79), GST-MDA-7 (80), Ad.mda-7 as single agent and in combination with radiation (81) | 84–86 |
| Neuroblastoma | Cells/mouse model | Ad.5/3-CTV | 87 |
| Pancreatic Cancer | Cells/mouse model | Ad.mda-7 as single agent and in combination with perillyl alcohol (83, 84) | 88, 89 |
| Esophageal squamous cell carcinoma | Cells/mouse model | Recombinant human IL-24 | 90 |
| Hepatocellular carcinoma | Cells | Ad.mda-7 (86), Ad.mda-7 (87) | 91, 92 |
| Colorectal cancer | Cells/mouse model | Ad.mda-7 (88), Ad.mda-7 (89), small-molecule compound SC144 (90) | 93–95 |
| Renal carcinoma | Cells/mouse model | GST-MDA-7 | 96 |
| Cervical Cancer | Cells/mouse model | Ad.mda-7 | 97 |
| Ovarian Cancer | Cells/mouse model | Ad.mda-7/Ad.RGD.pK7.mda-7/Ad.RGD.mda-7 (93), Ad.mda-7 (94) | 98, 99 |
| Osteosarcoma | Cells/mouse model | OA-IL-24 | 100 |
| Leukemia | Cells/mouse model | GST-MDA-7 | 101 |
| Lymphoma | Cells/mouse model | mda-7/IL-24 gene linked to a lentiviral vector | 102 |
Ad.mda-7: Recombinant non-replicating adenovirus expressing mda-7/IL-24.
Cancer Terminator Virus-CTV: replication competent cancer-selective adenovirus expressing mda-7/IL-24. MB: Microbubbles.
UTMD approach: ultrasound targeted microbubble destruction.
VV-IL-24: cancer-targeted vaccinia virus carrying the IL-24 gene.
Ad.5/3-mda-7: a recombinant Ad.5/3 virus delivering mda-7/IL-24.
GST-MDA-7: GST (glutathione-S-transferase) fusion protein of mda-7.
Ad.5/3-CTV: a recombinant Ad.5/3 virus delivering CTV.
Ad.RGD.pK7.mda-7 and Ad.RGD.mda-7: Infectivity-enhanced adenoviral vectors encoding mda-7.
OA-IL-24: oncolytic adenovirus expressing IL-24.