Table 21.

Margins of exposure (MOE) values for the incidence of cholangiofibrosis based on a scenario for chronic dietary exposure to the sum of furan, 2‐methylfuran and 3‐methylfuran across dietary surveys and age groups

Age group	MOE calculated from mean dietary exposure						MOE calculated from P95 dietary exposure
	Minimum		Median		Maximum		Minimum		Median		Maximum
	LB	UB	LB	UB	LB	UB	LB	UB	LB	UB	LB	UB
Infants	378	257	124	105	53	48	189	131	42	38	29	27
Toddlers	230	179	161	129	102	83	126	100	102	79	51	46
Other children	280	207	207	165	131	107	174	131	117	96	49	46
Adolescents	429	357	306	238	146	129	222	195	126	111	49	47
Adults	306	268	56	54	29	28	140	129	24	24	11	11
Elderly	238	214	56	54	24	24	67	66	22	22	11	10
Very elderly	247	214	63	61	20	19	82	77	27	27	16	16

N: number of dietary surveys; LB: lower bound; UB: upper bound; P95: 95th percentile

Note: the additive exposure has been calculated as mg/kg bw per day and not on a molar basis.