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. 2017 Oct 25;15(10):e05005. doi: 10.2903/j.efsa.2017.5005

Table C.8.

Data on the incidence of hepatocellular adenomas/carcinomas in female mice used for BMD analysis

Dose (mg/kg bw per day)a n hepatocellular adenomas and carcinomas n hepatocellular carcinomas n total Reference
0.0 3 0 36 Moser et al. (2009)
0.0 7 2 50 NTP (1993)
0.5 8 4 72 Moser et al. (2009)
1.0 6 2 53 Moser et al. (2009)
2.0 5 1 41 Moser et al. (2009)
4.0 12 2 36 Moser et al. (2009)
8.0 29 11 39 Moser et al. (2009)
8.0 34 7 50 NTP (1993)
15.0 50 27 50 NTP (1993)

N: number of animals; bw: body weight.

a

For a 5 days per week dosing regimen.