Table C.8.
Dose (mg/kg bw per day)a | n hepatocellular adenomas and carcinomas | n hepatocellular carcinomas | n total | Reference |
---|---|---|---|---|
0.0 | 3 | 0 | 36 | Moser et al. (2009) |
0.0 | 7 | 2 | 50 | NTP (1993) |
0.5 | 8 | 4 | 72 | Moser et al. (2009) |
1.0 | 6 | 2 | 53 | Moser et al. (2009) |
2.0 | 5 | 1 | 41 | Moser et al. (2009) |
4.0 | 12 | 2 | 36 | Moser et al. (2009) |
8.0 | 29 | 11 | 39 | Moser et al. (2009) |
8.0 | 34 | 7 | 50 | NTP (1993) |
15.0 | 50 | 27 | 50 | NTP (1993) |
N: number of animals; bw: body weight.
For a 5 days per week dosing regimen.