Table E.3.
Developmental and reproductive toxicity studies
| Chemical name [FL‐no] | Study type/duration | Species/sex No/group | Route | NOAEL mg/kg per day including information on possible maternal toxicity | Reference | Comments |
|---|---|---|---|---|---|---|
| (Isopropyl alcohol [02.079]) | Reproductive toxicity: two generations with 10 weeks of dosing prior to mating |
Rat/M, F 4/60 |
Gavage | 500 | Bevan et al. (1995) |
EPA Guideline compliance |
| Developmental toxicity: gestation days 6–15 |
Rat/F 4/25 |
Gavage |
400 (maternal) 400 (fetal) |
Tyl et al. (1994) |
EPA Guideline compliance |
|
| Developmental toxicity: gestation days 6–18 |
Rabbit/F 4/15 |
Gavage |
240 (maternal) 480 (fetal) |
Tyl et al. (1994) |
EPA Guideline compliance |
|
| Pentan‐3‐one [07.084] | Fertility screen: 28 daily doses with mating starting on day 10 |
Mouse/F 2/8 |
IP | 50 | Carlson et al. (1975) | Few details given in the paper |
| Pseudo‐ionone [07.198] | Developmental toxicity: gestation days 8 |
Hamster/F 3/20 (control) and 7 or 10 |
Oral | 960 | Willhite (1986) |
FL‐no: FLAVIS number; NOAEL: no observed adverse effect level.
M = Male; F = Female.
a
Summarised by JECFA, 51st meeting (JECFA, 1999a).