Table E.5.
Genotoxicity in vivo
| Chemical name | Test system | Test object | Route | Dose | Result | Reference | Comments |
|---|---|---|---|---|---|---|---|
| (Isopropyl alcohol [02.079]) | Micronucleus test | ICR Mouse (15 M & 15 F) | IP injection in 0.9% NaCl | 350–2,500 mg/kg | Negative | Kapp et al. (1993) | a |
| (Acetone [07.050]) | Micronucleus test | Chinese hamster (5 M & 5 F) | IP injection in corn oil | 865 mg/kg | Negative | Basler (1986) | a |
| (2‐Butanone [07.053]) | Micronucleus test | CD‐1 mice (5 M & 5 F) | IP injection in corn oil | LD20 (1.96 mL/kg) | Negative | O'Donoghue et al. (1988) | a |
| Micronucleus test | Chinese hamster (5 M & 5 F) | IP injection in corn oil | 411 mg/kg | Negative | Basler (1986) | a | |
| (4‐Methyl‐2‐pentanone [07.017]) | Micronucleus test | CD‐1 mice (5 M & 5 F) | IP injection in corn oil | LD20 (0.73 mL/kg) | Negative | Basler (1986) | a |
M = Male; F = Female; IP: intraperitoneal; LD20: lethal dose, 20%.
a
Summarised by JECFA, 51st meeting (JECFA, 1999a).