Table E.7.
Summary of in vivo genotoxicity data considered by the Panel in FGE.205Rev1
| Chemical name FL‐no | Test system in vivo | Test object | Route | Dose | Result | Reference | Comments |
|---|---|---|---|---|---|---|---|
|
Pent‐1‐en‐3‐one [07.102] |
Micronucleus Assay | Han Wistar Rat; M | Gavage | 0, 10, 20 and 40 mg/kg bw per day | Negative | Keig‐Shevlin (2015b,c) | |
| Comet assay | Han Wistar Rat; M | Gavage | Negativea , b | ||||
|
Oct‐1‐en‐3‐one [07.081] |
Comet assay | Han Wistar Rat; M | Gavage | 0, 45, 90 and 180 mg/kg bw per day | Negativea | Keig‐Shevlin (2015a) |
FL‐no: FLAVIS number; bw: body weight.
a
Scored in liver cells.
b
Scored in duodenum cells.