Fig. 1.

Landmarks in chemoenzymatic chemistry and the targeted chemoenzymatic transformation. a Pharmaceuticals accessed using chemoenzymatic synthesis. b Breakthroughs in chemoenzymatic methods development that rely on C–C bond and stereocenter formation at the reacting carbon atom(s), which provide streamlined retrosynthetic disconnections. c Current study involving the chemoenzymatic conversion of amides to enantioenriched diarylmethanols, a common motif in bioactive molecules and building block in stereoselective synthesis