Table 46.

Developmental and reproductive toxicity studies on DON in experimental animals

Species	n per group	Dose (mg/kg bw per day)	Route	Effect	NOAEL (mg/kg bw per day)	Reference
Reproductive toxicology
Mouse, Swiss Webster, weanling	7–20	0, 0.38, 0.75, 1.5, 2.0	Diet	Postnatal survival	0.38	Khera et al. (1984)
Rat, Sprague–Dawley, male/female	15/15	0, 0.25, 0.5, 1.0	Diet	Embryotoxicity/maternal toxicity	1.0	Khera et al. (1984)
Rat, Sprague–Dawley, male/female	10 m,25 f	2.0	Diet	Reduced fertility	2.0 (LOAEL)	Morrissey and Vesonder (1985)
Mouse, B6C3F1 IL‐6KO and WT	3–6	2.0	Diet	Body weight, epididymal weight	2.0 (LOAEL)	Sprando et al. (1999)
Rat, Sprague–Dawley, male	15–16	0, 0.5, 1.0, 2.5, 5.0	Gavage, 28 days	Reproductive endpoints	1.0	Sprando et al. (2005)
Developmental toxicity
Mouse, Swiss Webster, pregnant	15–19	0, 0.5, 1.0, 2.5, 5.0, 10.0, 15.0	Gavage,gestation days 8–11	Skeletal abnormalities	0.5	Khera et al. (1982)
Rat, Fischer, female	22–23	0, 0.06,0.24, 0.6	Diet	No teratogenic/reproductive effects	0.6	Morrissey et al. (1984)
Rabbit, New Zealand, female	13–15	0, 0.3, 0.6, 1.0, 1.6, 1.8, 2.0	Diet	Maternal and fetal weight	0.6	Khera et al. (1986)
Rat, Sprague–Dawley, pregnant	24	0.5, 1.0, 2.5, 5.0	Gavage, gestation day 6–19	Fetal toxicity Maternal toxicity	1.0 0.5	Collins et al. (2006)

n: number; bw: body weight; LOAEL: lowest‐observed‐adverse‐effect level; m: male; f: female.