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. 2017 Sep 11;15(9):e04718. doi: 10.2903/j.efsa.2017.4718

Table 56.

DON exposure estimates back‐calculated from the biomarker concentrations reported to EFSAa , b and compared to the dietary based exposure estimates for the sum of DON, 3‐Ac‐DON, 15‐Ac‐DON and DON‐3‐glucoside at the middle bound presented in Section 6.1.2.2.1 and Appendix F

Age group(age) MB exposure estimate from dietc Urinary DON and glucuronides b Exposure estimateafrom biomarker MB exposure estimate from dietc Urinary DON and glucuronidesb Exposure estimateafrom biomarker MB exposure estimate from dietc Urinary DON and glucuronidesb Exposure estimateafrom biomarker
μg/kg bw per day ng/mL μg/kg bw per day μg/kg bw per day ng/mL μg/kg bw per day μg/kg bw per day ng/mL μg/kg bw per day
UK Italy Norway
Children (3–9 years) 1.15 21.2 0.70 1.33 8.4 0.25 1.10 10.8 0.34
Adolescent (10–17 years) 0.60 20.0 1.14 0.80 7.7 0.40 0.60 8.5 0.50
Adults (18–64 years) 0.45 11.9 0.42 0.54 4.4 0.18 0.47 5.6 0.22
Elderly (65 years or >) 0.42 8.1 0.31 0.50 4.1 0.18 0.42 4.4 0.18
Pregnant women na 12.2 0.42 na 1.4 0.06 na 5.0 0.19
Vegetarian na 10.1 0.42 na 3.9 0.16 na 5.1 0.22

bw: body weight; na: not applicable; MB: middle bound.

a

Daily exposure is calculated based the DON and glucuronide biomarker and assumption of daily urine volume at 0.5 and 2 L for child and adult, and DON excretion percentage is estimated at 70%.

b

The individual urinary DON and glucuronide concentrations as ng/mL were extracted from the EFSA database as submitted to EFSA in the DON biomarker project in 2015 (Brera et al., 2015).

c

The chronic exposures for UK and Italy are the estimates from the diet as presented in this opinion (see Appendix F.1). The food consumption data reported for Denmark were used to compare to the exposure estimate from biomarker in Norway due to the lack of Norwegian food consumption data in the EFSA Comprehensive Food Consumption Database.