Table G.12.
Summary of concentration–response analysis of vomiting in pigs exposed to DON as reported by Williams et al. (1988)
| Models | Number of parameters | Minus Log‐likelihood | p‐value | AIC | BMC10 | BMCL10 | Comment |
|---|---|---|---|---|---|---|---|
| (mg/kg feed) | |||||||
| Full model | 12 | 18.93 | na | 61.86 | na | na | |
| Null (reduced) model | 1 | 32.75 | 0. 004 | 67.50 | na | na | |
| Probit | 2 | 22.84 | 0.65 | 49.68 | 4.64 | 3.31 | Not selected |
| Logistic | 2 | 23.14 | 0.59 | 50.28 | 4.89 | 3.53 | Not selected |
| LogProbit | 2 | 22.18 | 0.77 | 48.35 | 3.93 | 2.07 | Selected |
| LogLogistic | 2 | 22.30 | 0.75 | 48.60 | 3.93 | 1.95 | Selected |
| Multistage | 2 | 22.26 | 0.76 | 48.52 | 4.28 | 1.86 | Selected |
| Multistage Cancer | 1 | 22.29 | 0.82 | 46.59 | 3.97 | 1.84 | AIC minimum |
| Quantal‐Linear | 1 | 23.64 | 0.58 | 49.28 | 2.05 | 1.33 | Not selected |
| Weibull | 2 | 22.84 | 0.65 | 49.68 | 4.46 | 3.31 | Not selected |
| Gamma | No fit | ||||||
DON: deoxynivalenol.
The models selected to identify the lowest BMCL10 following EFSA guidance (EFSA Scientific Committee, 2017) are identified in the column ‘Comments’ and include the model with the lowest AIC.
BMC10: benchmark concentration response of 10%; BMCL10: 95% lower/upper confidence limit for the benchmark concentration response (BMR) of 10%; na: not available, including cases where the BMC/Ls were not calculated, the fit was incomplete, or serious or conflicting comments were noted (e.g. parameters reaching boundary).