Table G.14.
Summary of concentration–response analysis of incidence of vomiting in dogs reported by Hughes et al. (1999)
| Models | Number of parameters | Minus Log‐likelihood | p‐value | AIC | BMC10 | BMCL10 | Comment |
|---|---|---|---|---|---|---|---|
| (mg/kg feed) | |||||||
| Full model | 7 | 8.97 | na | 31.94 | na | na | |
| Null (reduced) model | 1 | 23.37 | < 0.001 | 48.74 | na | na | |
| Probit | 2 | 12.62 | 0.20 | 29.23 | 6.91 | 4.90 | Not selected |
| Logistic | 2 | 12.86 | 0.17 | 29.71 | 6.87 | 4.90 | Not selected |
| LogProbit | 2 | 12.28 | 0.25 | 28.56 | 6.85 | 5.17 | Selected |
| LogLogistic | 2 | 12.51 | 0.22 | 29.02 | 6.79 | 4.92 | Not selected |
| Multistage | Failed | ||||||
| Multistage Cancer | 1 | 14.73 | 0.07 | 31.46 | 4.22 | 2.48 | Not selected |
| Quantal‐Linear | 1 | 16.61 | 0.02 | 35.21 | 2.32 | 1.39 | Not selected |
| Weibull | 2 | 12.75 | 0.18 | 29.49 | 6.79 | 4.65 | Selected |
| Gamma | 2 | 12.39 | 0.34 | 26.77 | 6.83 | 5.05 | AIC minimum |
DON: deoxynivalenol.
The models selected to identify the lowest BMCL10 following EFSA guidance (EFSA Scientific Committee, 2017) are identified in the column ‘Comments’ and include the model with the lowest AIC.
BMC10: benchmark concentration response of 10%; BMCL10: 95% lower confidence limit for the benchmark concentration response (BMR) of 10%; na: not available, including cases where the BMC/Ls were not calculated, the fit was incomplete, or serious or conflicting comments were noted (e.g. parameters reaching boundary).