Table G.17.
Summary of dose–response analysis of incidence of vomiting/retching in mink exposed to DON reported by Wu et al. (2013a)
| Models | Number of parameters | Minus Log‐likelihood | p‐value | AIC | BMD10 | BMDL10 | Comment |
|---|---|---|---|---|---|---|---|
| (mg/kg bw per day) | |||||||
| Full model | 5 | 2.70 | na | 15.40 | na | na | |
| Null (reduced) model | 1 | 20.53 | 1 | 43.06 | na | na | |
| Probit | 2 | 2.70 | 1 | 9.41 | 0.037 | 0.010 | Selected |
| Logistic | 2 | 2.70 | 1 | 9.41 | 0.043 | 0.012 | Selected |
| LogProbit | 2 | 2.70 | 1 | 9.41 | 0.029 | 0.0067 | Selected |
| LogLogistic | 2 | 2.70 | 1 | 9.41 | 0.037 | 0.0067 | Selected |
| Multistage | 2 | no fit | |||||
| Multistage Cancer | 1 | 3.11 | 0.94 | 8.22 | 0.013 | 0.0037 | Selected |
| Quantal‐Linear | 1 | 4.45 | 0.48 | 10.89 | 0.0044 | 0.0022 | Not selected |
| Weibull | 2 | 2.70 | 1 | 9.41 | 0.032 | 0.0055 | Selected |
| Gamma(a) | 2 | 2.70 | 1 | 7.41 | 0.029 | 0.0057 | AIC minimum |
The models selected to identify the lowest BMDL10 following EFSA guidance (EFSA Scientific Committee, 2017) are identified in the column ‘Comments’ and include the model with the lowest AIC.
AIC: area under the curve; BMD10: benchmark dose response of 10%; BMDL10: 95% lower confidence limit for the benchmark dose response (BMR) of 10%; bw: body weight; na: not available, including cases where the BMD/Ls were not calculated, the fit was incomplete, or serious or conflicting comments were noted (e.g. parameters reaching boundary).