Table G.19.
Summary of dose–response analysis of incidence of vomiting/retching in mink exposed to 15‐Ac‐DON reported by Wu et al. (2013a)
| Models | Number of parameters | Minus Log‐likelihood | p‐value | AIC | BMD10 | BMDL10 | Comment |
|---|---|---|---|---|---|---|---|
| (mg/kg bw per day) | |||||||
| Full model | 5 | 2.70 | na | 15.50 | na | na | |
| Null (reduced) model | 2 | 20.53 | na | 43.06 | na | na | |
| Probit | 2 | 2.70 | 1 | 9.41 | 0.070 | 0.018 | Selected |
| Logistic | 2 | 2.70 | 1 | 9.41 | 0.084 | 0.019 | Selected |
| LogProbit | 2 | 2.70 | 1 | 9.41 | 0.047 | 0.0060 | Selected |
| LogLogistic | 2 | 2.70 | 1 | 9.41 | 0.071 | 0.0061 | Selected |
| Multistage | Failed | ||||||
| Multistage Cancer | 1 | 2.81 | 0.99 | 7.62 | 0.025 | 0.0047 | AIC minimum |
| Quantal‐Linear | 1 | 3.66 | 0.75 | 9.32 | 0.0074 | 0.0035 | Selected |
| Weibull | 2 | 2.70 | 1 | 9.41 | 0.057 | 0.0042 | Selected |
| Gamma | 2 | 2.70 | 1 | 9.41 | 0.0053 | 0.0041 | Selected |
The models selected to identify the lowest BMDL10 following EFSA guidance (EFSA Scientific Committee, 2017) are identified in the column ‘Comments’ and include the model with the lowest AIC.
BMD10: benchmark dose response of 10%; BMDL10: 95% lower confidence limit for the benchmark dose response (BMR) of 10%; bw: body weight; na: not available, including cases where the BMD/Ls were not calculated, the fit was incomplete, or serious or conflicting comments were noted (e.g. parameters reaching boundary).