Table C.1.
Chemical Name FL‐no | Test System in vivo | Test Object | Route | Dose | Result | Reference | Comments |
---|---|---|---|---|---|---|---|
p‐Mentha‐1,8‐dien‐7‐al [05.117] |
Micronucleus Assay | Male Han Wistar rats | Gavage | 175, 350 and 700 mg/kg bw per day | Negative | Beevers (2014a,b) | Reliable with restriction. Complies with GLP and mainly with OECD Test Guideline 474 (not clear if the bone marrow was exposed) |
Comet assay | Male Han Wistar rats | Gavage | Positive | Reliable without restriction. Complies with GLP. The study was performed shortly before publication of OECD Test Guideline 489; however, it is consistent with this guideline. Positive in liver, negative in duodenum |
bw: body weight; GLP: Good Laboratory Practice; OECD: Organisation for Economic Co‐operation and Development.