Table B.1.

In vitro genotoxicity studies on benzophenone [FL‐no: 07.032]

Chemical name FL‐no JECFA‐no	End‐point	Test system	Concentration	Results	Reference	Comments
Benzophenone 07.032 831	SOS/umuC assay	S. Typhimurium TA1535	0–1,000 μMa	Positive	Takemoto et al. (2002)	Study is reliable. Positive at the higher concentrations (100–1,000 μM) in the presence of metabolic activation. However, the relevance of this endpoint is low
			7.8–1,000 μg/mLa	Positive	Kotnik et al. (2016)	Study is reliable. Positive at the highest concentration in the presence of metabolic activation. However, the relevance of this endpoint is low
	Bacterial reverse mutation assay	S. Typhimurium TA98, TA100, TA1535, TA1537	10–2,000 μg/platea,d	Negative	CCRIS (2009)	Reliability cannot be evaluated (full study report not available)
			3–333 μg/plateb,e	Negative
			10–1,000 μg/plateb,e	Negative
			1–166 μg/platec,e	Negative
	Gene mutation in mammalian cells	L5178Y (tk+/−) mouse lymphoma cells	33–90 μg/mLc 35–145 μg/mLb	Negative
			8.9–142.8 μg/mLc 8.9–141.7 μg/mLb	Negative	Jeon et al. (2007)	Reliable with limitations (experimental details are not provided) 80% inhibitory concentration (IC80) was used as maximum concentration

^aWith and without metabolic activation.

^bWith metabolic activation.

^cWithout metabolic activation.

^dPlate‐incorporation.

^ePre‐incubation.