Table B.2.

In vivo genotoxicity studies on benzophenone [FL‐no: 07.032]

Chemical name FL‐no JECFA‐no	Test system in vivo	Test object	Route	Dose	Result	Reference	Comments
Benzophenone 07.032 831	Micronucleus assay in bone marrow	B6C3F1 male mice	Intraperitoneal	200, 300, 400, 500 mg/kg bw (solvent: corn oil)	Negative	NTP (2006)	Reliable without restriction. Three injections at 24 h intervals; sacrifice 24 h after 3rd injection. No toxicity to the bone marrow
	Micronucleus assay in peripheral blood polychromatic erythrocytes	B6C3F1 male and female mice	Oral (feed)	1,250, 2,500, 5,000, 10,000, 20,000 ppm	Negative		Reliable without restriction. Harvest at end of 14‐week dosing regimen. No toxicity to the bone marrow
		Male CBA mice	Intraperitoneal	500, 1,000, 2,000 mg/kg bw	Negative	Abramsson‐Zetterberg and Svensson (2011)	Reliable without restriction. Single intraperitoneal injection, peripheral blood sampled after 42 h
		Male NMRI mice		100, 250, 400, 600 mg/kg bw	Negative		Reliable without restriction. Single intraperitoneal injection, peripheral blood sampled after 42 h