Table 9.

Statistically significant changes in the incidence of primary tumours in rats; number of tumour bearing animals/number of animals examined (incidence in %)

Tumour type	0 mg/kg diet	25,000 mg/kg diet	50,000 mg/kg diet
Male rats
Adenomas of the pituitary gland	8/45 (18%)	17/46 (37%)*	17/43 (40%)*
Carcinomas of the pituitary gland	5/45 (11%)	0/46 (0)**	2/43 (5%)
Adenomas and carcinomas of the pituitary gland (all)	13/45 (29%)	17/46 (37%)	19/43 (44%)
Female rats
Phaeochromocytoma of the adrenal glands (benign)	0/50 (0)	5/50 (10%)*	6/50 (12%)*
Phaeochromocytoma of the adrenal glands (all)	1/50 (2%)	5/50 (10%)	6/50 (12%)

* Significant increase (p < 0.05); ** significant decrease (p < 0.05).