Table 7.
Summary of acute toxicity studies with laboratory animals
| Species | Route of administration/Purity of compound | LD50 (μg/kg bw) | References |
|---|---|---|---|
| Mouse |
Intraperitoneal TTX source unknown |
10.7 | Xu et al. (2003) |
| Mouse |
Intraperitoneala Purity: 99.8% |
9 (8.2–9.8) | Marcil et al. (2006) |
| Mouse |
Intraperitoneal Purity not reported |
10 | Kao and Fuhrman (1963) |
| Mouse |
Subcutaneous Purity not reported |
12.5 | Xu et al. (2003) |
| Mouse |
Subcutaneous Purity not reported |
10 | Kao (1966) |
| Mouse |
Intragastric Purity not reported |
532 | Xu et al. (2003) |
| Mouse |
Oral (gavage) Purity: 98% |
232 | Abal et al. (2017) |
| Rat |
Intramusculara Purity: 99.8% |
11.1 (10.5–11.7) | Marcil et al. (2006) |
bw: body weight; TTX: tetrodotoxin.
a
No experimental data provided.