Table 10.

Relative potencies (RPs) for TTX analogues, as determined in the Neuro2a‐assay

Compound	EC50 (nM)	RP	Reference
TTX	2.1 4.6 4.7	1	Kudo et al. (2014) Yotsu‐Yamashita et al. (2003) Saruhashi et al. (2016)
11‐deoxyTTX	130 270	0.016 0.017	Kudo et al. (2014) Yotsu‐Yamashita et al. (2003)
6,11‐dideoxyTTX	400	0.056	Kudo et al. (2014)
11‐oxoTTX	2.9	1.6	Saruhashi et al. (2016)
6‐deoxyTTX	6.5	0.32	Kudo et al. (2014)

EC₅₀: Effective concentration 50%.