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. Author manuscript; available in PMC: 2020 Feb 10.
Published in final edited form as: Cell Rep. 2019 Dec 17;29(12):3997–4009.e5. doi: 10.1016/j.celrep.2019.11.070

Figure 3. Viral Library Profile Dynamics Can Be Reproduced in Single-Virus Experiments in a A/Puerto Rico/8/1934 (H1N1) Background In Vivo.

Figure 3.

(A) Three representative viruses showing different viral trends in the library were selected based on differences in barcode abundance.

(B–D) Single-virus infections were conducted in triplicate using 10-day-old embryonated chicken eggs (B), MDCK cells (C), and 8-week-old C57BL/6 mice (D). Viral replication was quantified at different time points post-infection.

(E) Body weight loss of infected mice was monitored daily.

Error bars depict the SD. *p < 0.05.