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. 2020 Jan 29;56(3):750–760. doi: 10.3892/ijo.2020.4972

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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The PSC cell line analogue exhibited an increased Twist1 expression, EMT phenotype, VM formation and migratory and invasive ability. (A) NSCLC cells treated with TGFßl exhibited a decreased E-cadherin and increased Vimentin expression. Twist1 and p-Smad2/3 expression was induced, while that of Slug and Snail expression was not altered following TGFßl treatment in SK-MES-1 cells. (B) Immunofluorescence assays revealed a decreased E-cadherin expression and an increased Vimentin expression, and 3D Matrigel culture revealed VM formation following TGFßl treatment. (C-E) Increased wound closure (C), migratory (D), and invasive (E) ability was observed following TGFßl treatment. PSC, pulmonary sarcomatoid carcinoma; EMT, epithelial-mesenchymal transition; PSCC, pulmonary squamous carcinoma; VM, vasculogenic mimicry.