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. 2020 Jan 10;56(3):697–708. doi: 10.3892/ijo.2020.4958

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Copyright: © Feng et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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iTRAQ proteomics profiling of RM tumors overexpressing PAX2. (A) An overview of the workflow employed in this study. Two iTRAQ replicates were carried out to ensure the consistency and reliability of the results. (B) Expression of PAX2 in allograft RM tumors was confirmed by immunohisto-chemistry. (C) Reproducibility analysis of 2 repeated trials by Pearson's correlation coefficient. (D) Summary of identified and quantified proteins. (E) KEGG pathway-based enrichment analysis of up-regulated proteins (RM-PAX2 vs. RM-WPI). (F) Fatty acid metabolism. Enzymes upregulated by PAX2 overex-pression are indicated in red color. PAX2, paired box 2; Acsl, long-chain-fatty-acid-CoA ligase 1; Cpt1, carnitine O-palmitoyltransferase 1; Cpt2, Carnitine O-palmitoyltransferase 2; Acadl, long-chain specific acyl-CoA dehydrogenase, mitochondrial; Acadvl, very long-chain specific acyl-CoA dehydrogenase, mitochondrial; Acads, short-chain specific acyl-CoA dehydrogenase, mitochondria; Acadm, medium-chain specific acyl-CoA dehydrogenase, mitochondrial; Echs1, Enoyl-CoA hydratase; Ehhadh, peroxisomal bifunctional enzyme; Acaa1, 3-ketoacyl-CoA thiolase A; Acaa2, 3-ketoacyl-CoA thiolase, mitochondrial.